Clinical characteristics and associated factors of pediatric acute disseminated encephalomyelitis patients with MOG antibodies: a retrospective study in Hangzhou, China.

Abstract

BACKGROUND:

To explore the clinical characteristics and related factors of children with acute disseminated encephalomyelitis (ADEM) with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody.

METHODS:

A retrospective study was conducted and enrolled pediatric ADEM patients who underwent serum MOG antibody detection from May 2017 to August 2020. The patients were divided into two groups: MOG- immunoglobulin G (IgG) positive (n = 35) and MOG-IgG negative (n = 50). We analyzed the clinical characteristics of MOG-IgG-positive ADEM pediatric patients and conducted a comparative analysis between the two groups.

RESULTS:

Thirty-five patients (21 males and 14 females) in the MOG-IgG-positive group with encephalopathy, multifocal neurological symptoms, and typical magnetic resonance imaging (MRI) abnormalities were enrolled. They usually had a favorable outcome, while some suffered from relapse. Compared to the MOG-IgG-negative group, MOG-IgG-positive ADEM patients had a longer disease duration (median: 10 vs. 6 days), more meningeal involvement (31.4% vs. 8%) and frontal lobe involvement (82.8% vs. 68%), higher relapse rates (14.3% vs. 2%), lower serum tumor necrosis factor (1-12.4 pg/ml, median 1.7 vs. 1-34 pg/ml, median 2.2) and interferon-gamma (1-9.4 pg/ml, median 1.3 vs. 1-64 pg/ml, median 3) (P < 0.05, respectively). Multivariate logistic regression analysis showed that the longer disease duration, meningeal involvement and frontal lobe involvement were the correlated factors of patients with ADEM with MOG antibody (P < 0.05).

CONCLUSIONS:

Our findings provide clinical evidence that MOG-IgG positivity is associated with longer disease duration, meningeal involvement, and frontal lobe involvement.

• Authors: Jue Shen, Donghui Lin, Tiejia Jiang, Feng Gao, Kewen Jiang
• Journal: BMC neurology (BMC Neurol) Vol. 22 Issue 1 Pg. 418 (Nov 09 2022) ISSN: 1471-2377 [Electronic] England
• PMID: 36352355 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Myelin-Oligodendrocyte Glycoprotein
• Autoantibodies
• Immunoglobulin G

Topics

• Male
• Female
• Humans
• Myelin-Oligodendrocyte Glycoprotein
• Retrospective Studies
• Autoantibodies
• Encephalomyelitis, Acute Disseminated
• Immunoglobulin G
• Recurrence