Abstract | BACKGROUND: CASE PRESENTATION: A 14-year-old female came to our facility complaining of trouble walking and bluish-black discoloration on her neck, elbows, forehead, and knees that had been present for eight months. The patient had undergone enucleation of the left eye due to retinoblastoma, followed by 40 cycles of radiation therapy and 13 cycles of chemotherapy with Cyclophosphamide, Etoposide, Carboplatin, Vincristine, and Dactinomycin. Her serum LDH and CPK levels were high, and she tested positive for ANA. The muscle biopsy was consistent with the changes of DM. When electromyography was performed, it revealed tiny, fibrillating, polyphasic motor unit potentials and sharp, positive waves that were suggestive with DM. A diagnosis of JDM was made after taking into account the symptoms, biochemical data, muscle biopsy, and electromyography results. The patient's symptoms started to get better once methotrexate and oral corticosteroids were started. CONCLUSION: This case report emphasises the value of ongoing observation after cancer chemotherapy because specific cutaneous and muscle symptoms may lead paediatricians to consider the possibility of chemotherapy-induced JDM, which is uncommon in young patients.
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Authors | Keta Vagha, Chitturi Venkata Sai Akhil, Spandana Madirala, Ashish Varma, Mahaveer Lakra, Jayant Vagha |
Journal | BMC pediatrics
(BMC Pediatr)
Vol. 22
Issue 1
Pg. 623
(10 31 2022)
ISSN: 1471-2431 [Electronic] England |
PMID | 36316673
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
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Topics |
- Adult
- Humans
- Female
- Adolescent
- Dermatomyositis
(chemically induced, diagnosis, drug therapy)
- Retinoblastoma
- Electromyography
- Retinal Neoplasms
- Antineoplastic Agents
(therapeutic use)
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