Peptides as Potentially Anticarcinogenic Agent from Functional Canned Meat Product with Willow Extract.

Abstract

The aim of the study was to demonstrate canned pork as a functional meat product due to the presence of potentially anti-cancer factors, e.g., (a) bioactive peptides with potential activity against cancer cells; (b) lowering the content of sodium nitrite and with willow herb extract. In silico (for assessing the anticancer potential of peptides) and in vitro (antiproliferation activity on L-929 and CT-26 cell lines) analysis were performed, and the obtained results confirmed the bioactive potential against cancer of the prepared meat product. After 24 h of incubation with peptides obtained from meat product containing lyophilized herb extract at a concentration of 150 mg/kg, the viability of both tested cell lines was slightly decreased to about 80% and after 72 h to about 40%. On the other hand, after 72 h of incubation with the peptides obtained from the variant containing 1000 mg/kg of freeze-dried willow herb extract, the viability of intestinal cancer cells was decreased to about 40%, while, by comparison, the viability of normal cells was decreased to only about 70%.

• Authors: Karolina M Wójciak, Paulina Kęska, Monika Prendecka-Wróbel, Karolina Ferysiuk
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 27 Issue 20 (Oct 16 2022) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 36296529 (Publication Type: Journal Article)

Chemical References

• Sodium Nitrite
• Peptides
• Plant Extracts

Topics

• Meat Products
• Salix
• Sodium Nitrite
• Peptides (pharmacology)
• Plant Extracts (pharmacology)
• Meat