Seizures in patients with IDH-mutated lower grade gliomas.

Abstract

PURPOSE:

Most patients with Lower Grade Gliomas (LGG) present with epileptic seizures. Since the advent of molecular diagnostics, more homogenous sub-entities have emerged, including the isocitrate dehydrogenase-mutated (IDH-mutated) astrocytomas and 1p19q-codeleted oligodendrogliomas. We aimed to describe the occurrence of seizures in patients with molecularly defined LGG pre- and postoperatively and to analyze factors affecting seizure status postoperatively.

METHODS:

A population-based cohort of 130 adult patients with IDH-mutated WHO grade 2 or 3 astrocytomas and oligodendrogliomas was assessed pertaining to seizure burden before and after surgery.

RESULTS:

Fifty-four (79.4%) patients with astrocytoma and 45 (72.6%) patients with oligodendroglioma had a history of seizures before surgery. At 12 months postoperatively, 51/67 (76.1%) patients with astrocytoma and 47/62 (75.8%) patients with oligodendrogliomas were seizure free. In a multivariable logistic regression analysis, lower extent of resection (EOR) (OR 0.98; 95% CI 0.97-1.00, p = 0.01) and insular tumor location (OR 5.02; 95% CI 1.01-24.87, p = 0.048) were associated with presence of seizures within 1 year postoperatively in the entire LGG cohort. In sub-entities, EOR was in a similar manner associated with seizures postoperatively in astrocytomas (OR 0.98; 95% CI 0.96-0.99, p < 0.01) but not in oligodendrogliomas (p = 0.34).

CONCLUSION:

Our results are well in line with data published for non-molecularly defined LGG with a large proportion of patients being seizure free at 1 year postoperative. Better seizure outcome was observed with increased EOR in astrocytomas, but this association was absent in oligodendrogliomas.

• Authors: Louise Carstam, Isabelle Rydén, Asgeir Store Jakola
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 160 Issue 2 Pg. 403-411 (Nov 2022) ISSN: 1573-7373 [Electronic] United States
• PMID: 36258151 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Isocitrate Dehydrogenase

Topics

• Adult
• Humans
• Isocitrate Dehydrogenase (genetics)
• Oligodendroglioma (complications, genetics, surgery)
• Brain Neoplasms (complications, genetics, surgery)
• Glioma (complications, genetics, surgery)
• Astrocytoma (complications, genetics, surgery)
• Seizures (genetics)
• Mutation