Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC‑1α/FNDC5 signaling pathway.

Abstract	Postoperative cognitive dysfunction is a severe neurological complication. How to improve the cognitive impairment caused by sevoflurane, a most common inhaled anesthetic, remains a question worthy of studying. Isovitexin (IVX) is a trihydroxyl flavonoid that is a naturally bioactive ingredient found in various medicinal plants and has antioxidant, anti‑inflammatory and neuroprotective properties. The role of IVX in anesthetic‑induced nerve injury is rarely reported and the mechanisms are unclear. In this study, we found that IVX improved the cognitive dysfunction induced by sevoflurane in rats. It inhibited sevoflurane‑induced cell apoptosis. In addition, IVX increased sevoflurane‑induced autophagy in rat brain. Mechanically, IVX activated the PGC‑1α/FNDC5 pathway in rat brain, and depletion of FNDC5 could inhibit the neuroprotective function of IVX. In conclusion, our results suggested that IVX restored sevoflurane‑induced cognitive dysfunction by mediating autophagy through the activation of the PGC‑1α/FNDC5 pathway.
Authors	Yuanyuan Guo, Qibin Chen, Bin Wu, Lin Sun
Journal	Acta neurobiologiae experimentalis (Acta Neurobiol Exp (Wars)) Vol. 82 Issue 3 Pg. 373-379 ( 2022) ISSN: 1689-0035 [Electronic] Poland
PMID	36214719 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents Antioxidants FNDC5 protein, rat Fibronectins Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Ppargc1a protein, rat Sevoflurane Apigenin isovitexin
Topics	Animals Anti-Inflammatory Agents (pharmacology) Antioxidants (pharmacology) Apigenin (pharmacology) Apoptosis Autophagy Cognitive Dysfunction (chemically induced, drug therapy) Fibronectins (metabolism) Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (metabolism) Rats Rats, Sprague-Dawley Sevoflurane (adverse effects) Signal Transduction

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