Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis.

Abstract

BACKGROUND:

Oncostatin M receptor is an interleukin 6 receptor with great influence on inflammation and cancer progression. However, the function of oncostatin M receptor in oral squamous cell carcinoma remains unknown.

METHODS:

Oncostatin M receptor expression was explored with TIMER and TCGA databases. The mRNA and protein expressions of oncostatin M receptor were detected in oral tissues. The association between oncostatin M receptor expression and clinicopathological characteristics was analyzed, and the prognostic value of oncostatin M receptor was determined. Immune statues of oncostatin M receptor were analyzed by TIMER and TISIDB. The underlying mechanisms of oncostatin M receptor in oral squamous cell carcinoma was also explored preliminarily.

RESULTS:

Oncostatin M receptor was dysregulated in many cancers. Both mRNA and protein levels of oncostatin M receptor in oral squamous cell carcinoma tissues were significantly higher than that in normal oral tissues. Oncostatin M receptor expression was connected to differentiation, lymph node metastasis, tumor node metastasis (TNM) stage, perineural invasion and vascular invasion. Oncostatin M receptor expression was an independent prognostic factor associated with overall survivals. Oncostatin M receptor expression was significantly related to CD8+ T cell and interleukin 6 receptor. High oncostatin M receptor expression was associated with focal adhesion, extracellular matrix (ECM) receptor interaction, and JAK/STAT signaling pathway.

CONCLUSION:

Oncostatin M receptor was overexpressed in oral squamous cell carcinoma and related to overall survival. Oncostatin M receptor expression has potential to become an effective prognostic biomarker for oral squamous cell carcinoma patients.

• Authors: Qifeng Geng, Jing Wang, Wei Zhang, Wei Zhou, Genxiong Tang, Mingyan Gu
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 52 Issue 2 Pg. 136-144 (Feb 2023) ISSN: 1600-0714 [Electronic] Denmark
• PMID: 36207791 (Publication Type: Journal Article)
• Copyright: © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Receptors, Oncostatin M
• RNA, Messenger

Topics

• Humans
• Squamous Cell Carcinoma of Head and Neck
• Carcinoma, Squamous Cell (pathology)
• Receptors, Oncostatin M (metabolism)
• Mouth Neoplasms
• Signal Transduction
• Head and Neck Neoplasms
• Prognosis
• RNA, Messenger