Abstract | BACKGROUND: CASE PRESENTATION: A 35-year-old female with breast cancer was referred to our hospital. Histopathological examination of the tumor showed that it was triple-negative breast cancer with high proliferation marker. Preoperative positron emission tomography-computed tomography showed abnormal uptake in the left cerebellar hemisphere in addition to the right breast and axillary lymph node. Brain T2-weighted magnetic resonance imaging revealed hyperintense bands in the left cerebellar hemisphere lesion, which demonstrated a "tiger-stripe" appearance. The patient's mother had died of endometrial cancer. Subsequently, she underwent genetic testing, leading to a diagnosis of Cowden syndrome with a pathogenic variant c.823_840del.18 at exon 8 in PTEN. She was treated with neoadjuvant chemotherapy of eribulin and cyclophosphamide followed by adriamycin and cyclophosphamide. However, her tumors increased after these treatments. She was immediately surgically treated and received adjuvant chemotherapy of capecitabine. Unfortunately, the cancer recurred in the lung nine months after surgery. We then administered paclitaxel and bevacizumab therapy, but the disease rapidly progressed. Consequently, the patient died due to breast cancer about three months after recurrence. CONCLUSION:
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Authors | Aiko Sueta, Masako Takeno, Lisa Goto-Yamaguchi, Mai Tomiguchi, Toko Inao, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto |
Journal | World journal of surgical oncology
(World J Surg Oncol)
Vol. 20
Issue 1
Pg. 279
(Sep 03 2022)
ISSN: 1477-7819 [Electronic] England |
PMID | 36057718
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Cyclophosphamide
- PTEN Phosphohydrolase
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Topics |
- Adult
- Cyclophosphamide
- Endometrial Neoplasms
(pathology)
- Female
- Germ-Line Mutation
- Hamartoma Syndrome, Multiple
(complications, diagnosis, genetics)
- Humans
- PTEN Phosphohydrolase
(genetics)
- Triple Negative Breast Neoplasms
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