Removal of cardiac AL amyloid with positive remodelling of cardiomyocytes and of restrictive cardiomyopathy.

Abstract

Herein, we describe histological mobilization of light chain cardiac amyloid documented by sequential left ventricular endomyocardial biopsies. These findings were associated with positive remodelling of cardiomyocytes and of restrictive cardiomyopathy resulting from 14 courses of chemotherapy over 17 years of time. Histological and ultrastructural findings of light chain cardiac amyloid removal led to increase in cardiomyocyte dimension and electrocardiogram voltages, reduction of biventricular wall thickness with improvement of left ventricular diastolic function, and NYHA class shifting from III to I.

• Authors: Andrea Frustaci, Romina Verardo, Nicola Galea, Maria Alfarano, Luigi Sansone, Matteo Antonio Russo, Cristina Chimenti
• Journal: ESC heart failure (ESC Heart Fail) Vol. 9 Issue 6 Pg. 4330-4334 (12 2022) ISSN: 2055-5822 [Electronic] England
• PMID: 36056647 (Publication Type: Case Reports, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

Chemical References

• Amyloid

Topics

• Humans
• Cardiomyopathy, Restrictive (diagnosis, metabolism)
• Myocytes, Cardiac (metabolism)
• Myocardium (pathology)
• Amyloid (metabolism)
• Biopsy