Mesoporous Polydopamine-Based Nanovehicles as a Versatile Drug Loading Platform to Enable Tumor-Sufficient Synergistic Therapy.

Abstract

The combination of photothermal therapy and chemotherapy are developing as a promising clinical strategy but it urgently needs the high exploration of intelligent multifunctional drug delivery nanovectors. In this paper, we used a versatile method to construct mesoporous polydopamine nanovehicles (MPDA) with the dendritic mesopores loaded with a clinical chemotherapeutic drug, Doxorubicin (MPDA@DOX). The monodisperse nanoagents are spherical with a size of ∼160 nm and pore size of approximately 10 nm. MPDA could efficiently delivery DOX with π-π stacking interaction and acts as the potent photothermal agents. Importantly, MPDA@DOX are preferentially internalized by cancerous cells, then bursting drug release and local hyperthermia generation were observed in conditions representative of the cytoplasm in tumor cells that highly synergistic cell killing effect were found under 808 nm laser irradiation. The fluorescent imaging results of human breast tumor bearing murine model evidenced that MPDA delivery platform have excellent tumor precise targeting effect and in vivo tumor ablation experiment further revealed that MPDA@DOX showed markedly eradicated tumor growth capability under laser exposure. Therefore, this work provided a fascinating strategy based on biocompatible MPDA based drug delivery system for malignant tumors eradication via synergistic therapy.

• Authors: Suhua Jiang, Fukai Zhu, Xiaoxuan Ji, Jiaqi Li, Haina Tian, Bingli Wang, Luanmei Lu, Peiyuan Wang
• Journal: ChemMedChem (ChemMedChem) Vol. 17 Issue 19 Pg. e202200360 (10 06 2022) ISSN: 1860-7187 [Electronic] Germany
• PMID: 36000799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 Wiley-VCH GmbH.

Chemical References

• Diazonium Compounds
• Indoles
• Pharmaceutical Preparations
• Polymers
• Pyridines
• polydopamine
• 3-(2'-pyridyldithio)benzyldiazoacetate
• Doxorubicin

Topics

• Animals
• Diazonium Compounds
• Doxorubicin (pharmacology, therapeutic use)
• Drug Delivery Systems (methods)
• Drug Liberation
• Humans
• Indoles
• Mice
• Nanoparticles
• Neoplasms (drug therapy)
• Pharmaceutical Preparations
• Phototherapy (methods)
• Polymers
• Pyridines