Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Historically, the only treatment options for patients with hypersensitivity pneumonitis were antigen avoidance and corticosteroids, although other immunosuppressive therapies are increasingly endorsed by experts in the field. There is accumulating evidence that antifibrotic medications can be useful as a second-line therapy in some patients with fibrotic hypersensitivity pneumonitis who have progression despite immunosuppression. There remains no direct comparison of immunosuppressive vs. antifibrotic medication for the management of fibrotic hypersensitivity pneumonitis, but some clinical, radiological and pathological features may suggest greater likelihood of benefit from one option or the other. SUMMARY: We anticipate that future treatment of fibrotic hypersensitivity pneumonitis will consider a variety of patient features to suggest the most prominent underlying biology that will then be used to guide initial pharmacotherapy; however, additional data are still needed.
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Authors | Monica L Mullin, Andrew Churg, Christopher J Ryerson |
Journal | Current opinion in pulmonary medicine
(Curr Opin Pulm Med)
Vol. 28
Issue 5
Pg. 421-431
(09 01 2022)
ISSN: 1531-6971 [Electronic] United States |
PMID | 35861479
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
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Topics |
- Alveolitis, Extrinsic Allergic
(diagnosis, drug therapy)
- Cohort Studies
- Fibrosis
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Lung Diseases, Interstitial
(diagnosis)
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