TRK Inhibition with Entrectinib in Metastatic Salivary Secretory Carcinoma (SC): A Case Report.

Abstract

NTRK gene fusions are rare oncogenic driver mutations that can be found in a broad range of neoplasms. In secretory carcinoma (SC), ETV6-NTRK3 gene fusion is seen in a majority of the cases and represents a druggable target for patients with advanced disease in the absence of a currently accepted standard of care. In our case, we describe a patient with recurrent, metastatic SC treated with first line entrectinib with clinically meaningful, durable ongoing response after 49 months. The patient experienced grade 1 fatigue, dysgeusia, skin sensitivity, arthralgias, an increase in serum creatinine, and weight-gain as well as grade 2 hypotension which resolved after a dose reduction. Entrectinib is a well-tolerated treatment with the potential for durable responses and TRK inhibition should be considered the standard of care in SC and other NTRK gene fusion-positive advanced neoplasms without acceptable alternative treatment options.

• Authors: Matthew S Ernst, John T Lysack, Martin D Hyrcza, Shamir P Chandarana, Desiree Hao
• Journal: Current oncology (Toronto, Ont.) (Curr Oncol) Vol. 29 Issue 6 Pg. 3933-3939 (05 31 2022) ISSN: 1718-7729 [Electronic] Switzerland
• PMID: 35735423 (Publication Type: Case Reports)

Chemical References

• Benzamides
• Indazoles
• entrectinib

Topics

• Benzamides
• Breast Neoplasms
• Carcinoma (genetics, pathology)
• Gene Fusion
• Humans
• Indazoles