Modifiable risk factors associated with cardiovascular disease and mortality in China: a PURE substudy.

Abstract

AIMS:

To examine the incidence of cardiovascular disease (CVD) and mortality in China and in key subpopulations, and to estimate the population-level risks attributable to 12 common modifiable risk factors for each outcome.

METHODS AND RESULTS:

In this prospective cohort of 47 262 middle-aged participants from 115 urban and rural communities in 12 provinces of China, it was examined how CVD incidence and mortality rates varied by sex, by urban-rural area, and by region. In participants without prior CVD, population-attributable fractions (PAFs) for CVD and for death related to 12 common modifiable risk factors were assessed: four metabolic risk factors (hypertension, diabetes, abdominal obesity, and lipids), four behavioural risk factors (tobacco, alcohol, diet quality, and physical activity), education, depression, grip strength, and household air pollution. The mean age of the cohort was 51.1 years. 58.2% were female, 49.2% were from urban areas, and 59.6% were from the eastern region of China. The median follow-up duration was 11.9 years. The CVD was the leading cause of death in China (36%). The rates of CVD and death were 8.35 and 5.33 per 1000 person-years, respectively, with higher rates in men compared with women and in rural compared with urban areas. Death rates were higher in the central and western regions of China compared with the eastern region. The modifiable risk factors studied collectively contributed to 59% of the PAF for CVD and 56% of the PAF for death in China. Metabolic risk factors accounted for the largest proportion of CVD (PAF of 41.7%), and hypertension was the most important risk factor (25.0%), followed by low education (10.2%), high non-high-density lipoprotein cholesterol (7.8%), and abdominal obesity (6.9%). The largest risk factors for death were hypertension (10.8%), low education (10.5%), poor diet (8.3%), tobacco use (7.5%), and household air pollution (6.1%).

CONCLUSION:

Both CVD and mortality are higher in men compared with women, and in rural compared with urban areas. Large reductions in CVD could potentially be achieved by controlling metabolic risk factors and improving education. Lowering mortality rates will require strategies addressing a broader range of risk factors.

• Authors: Sidong Li, Zhiguang Liu, Philip Joseph, Bo Hu, Lu Yin, Lap Ah Tse, Sumathy Rangarajan, Chuangshi Wang, Yang Wang, Shofiqul Islam, Weida Liu, Fanghong Lu, Yindong Li, Yan Hou, Deren Qiang, Qian Zhao, Ning Li, Rensheng Lei, Di Chen, Aiying Han, Guoqin Liu, Peng Zhang, Yahong Zhi, Chunmei Liu, Jinkui Yang, Aobulikasimu Resalaiti, Haibin Ma, Yuanting Ma, Yu Liu, Xiaojie Xing, Quanyong Xiang, Zhengrong Liu, Yundong Sheng, Jinghua Tang, Lisheng Liu, Salim Yusuf, Wei Li
• Journal: European heart journal (Eur Heart J) Vol. 43 Issue 30 Pg. 2852-2863 (08 07 2022) ISSN: 1522-9645 [Electronic] England
• PMID: 35731140 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. All rights reserved. For permissions, please e-mail: [email protected].

Topics

• Cardiovascular Diseases
• China (epidemiology)
• Female
• Humans
• Hypertension (epidemiology)
• Male
• Middle Aged
• Obesity (complications)
• Obesity, Abdominal (complications, epidemiology)
• Prospective Studies
• Risk Factors