Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents.

Abstract

Natural cytokinines are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of aryl carbamate, pyridyl urea, and aryl urea cytokinine analogs with alkyl and chlorine substitutions and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H2O2 and CoCl2 models. Aryl carbamates with the oxamate moiety were selectively anti-proliferative for the cancer cell lines tested, while the aryl ureas were inactive. In the cytoprotection studies, the same aryl carbamates were able to counteract the CoCl2 cytotoxicity by 3-8%. The possible molecular targets of the aryl carbamates during the anti-proliferative action were the adenosine A2 receptor and CDK2. The obtained results are promising for the development of novel anti-cancer therapeutics.

• Authors: Maxim Oshchepkov, Leonid Kovalenko, Antonida Kalistratova, Maria Ivanova, Galina Sherstyanykh, Polina Dudina, Alexey Antonov, Anastasia Cherkasova, Mikhail Akimov
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 27 Issue 11 (Jun 04 2022) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 35684552 (Publication Type: Journal Article)

Chemical References

• Carbamates
• Halogens
• Chlorine
• Urea
• Hydrogen Peroxide

Topics

• Carbamates (pharmacology)
• Cell Line
• Chlorine (chemistry)
• Halogens (chemistry)
• Hydrogen Peroxide (chemistry)
• Structure-Activity Relationship
• Urea (pharmacology)