Rapid and sensitive multiplex detection of COVID-19 antigens and antibody using electrochemical immunosensor-/aptasensor-enabled biochips.

Abstract

We report protein- and aptamer-based electrochemical biochips for low-cost, one-step, sensitive and accurate multiplex detection of SARS-CoV-2 spike (S) and nucleocapsid (N) proteins, and IgG antibody in unprocessed clinical samples, allowing citizens to achieve rapid diagnosis at home or in community settings.

• Authors: Fuze Jiang, Zhen Xiao, Ting Wang, Jiajia Wang, Lihua Bie, Lanja Saleh, Kathrin Frey, Lianjun Zhang, Jing Wang
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 58 Issue 52 Pg. 7285-7288 (Jun 28 2022) ISSN: 1364-548X [Electronic] England
• PMID: 35678120 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Spike Glycoprotein, Coronavirus
• spike protein, SARS-CoV-2

Topics

• Antibodies, Viral
• Biosensing Techniques
• COVID-19 (diagnosis)
• Electrochemical Techniques
• Humans
• Immunoassay
• SARS-CoV-2
• Spike Glycoprotein, Coronavirus