High Inflammatory Factor Levels Increase Cardiovascular Complications in Diabetic Patients Undergoing Coronary Artery Bypass Grafting.

Abstract

Objective:

To investigate the association between inflammation and clinical outcomes of coronary artery bypass grafting (CABG) in diabetic patients.

Methods:

A total of 300 diabetic patients with coronary heart disease who underwent CABG were selected. Patients were divided into a group with cardiovascular events (32 in the MACCE group) and a group without cardiovascular events (268 in the non-MACCE group) according to whether cardiovascular events occurred within 30 days. The differences in clinical parameters; serum levels of TNF-α, IL-6, IL-18, IL-1β, and CRP; factors associated with the occurrence of MACCE; and risk factors affecting the midterm all-cause mortality of patients were compared between the two groups.

Results:

The serum levels of TNF-α, IL-6, IL-18, and CRP in the MACCE group were significantly higher than those in the non-MACCE group (p < 0.05). Gender, smoking, hyperlipidemia, duration of diabetes, and levels of TNF-α, IL-6, IL-18, and CRP were closely related to the occurrence of MACCE. The Kaplan-Meier survival analysis evaluation results showed that the levels of IL-6 and CRP significantly affected the midterm all-cause mortality rate (p < 0.05). Multivariate Cox regression analysis showed that the advanced age, hypertension, hyperlipidemia, long duration of diabetes, elevated serum IL-6, and CRP levels could be used as risk factors for midterm all-cause mortality.

Conclusions:

Inflammation levels in diabetic patients are associated with complications and midterm all-cause mortality in patients undergoing coronary artery bypass grafting.

• Authors: Jie Chen, Qiyong Wu, Haifeng Shi, Yong Zhang, Tao Wang, Ruohan Yin, Changjie Pan
• Journal: BioMed research international (Biomed Res Int) Vol. 2022 Pg. 7151414 ( 2022) ISSN: 2314-6141 [Electronic] United States
• PMID: 35637754 (Publication Type: Journal Article, Retracted Publication)
• Copyright: Copyright © 2022 Jie Chen et al.

Chemical References

• Interleukin-18
• Interleukin-6
• Tumor Necrosis Factor-alpha

Topics

• Coronary Artery Bypass
• Coronary Artery Disease (complications, surgery)
• Diabetes Mellitus
• Humans
• Inflammation (complications)
• Interleukin-18
• Interleukin-6
• Tumor Necrosis Factor-alpha