[Advances in several important antimicrobial lipopeptids from Bacillus spp.]
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| Abstract |
Bacillus spp. are probiotics and can secrete a variety of natural antimicrobiol active substances, of which lipopeptides are an important class. Up to now, about 90 lipopeptides have been identified, and most of them are cyclic lipopeptides. surfactin, iturin, fengycin, bacillomycin and polymyxins are widely studied, and the first three have huge potential for application due to their properties of surfactants and anti-fungal, anti-bacterial, anti-viral, anti-tumor and anti-inflammatory functions. In this paper, the research progress in the structure, function, synthesis regulation, separation, purification and production of surfactin, iturin and fengycin was reviewed. Synthetic biology is a vital means to increase the yield of lipopeptides, and in the future, lipopeptides can be used in crop cultivation, animal farming, food, medicine and petroleum industries as well as environmental protection. Future research should be strengthened on the discovery of new lipopeptides, synthesis of high-activity lipopeptides, economical production of lipopeptides on a large scale and their safety evaluation.
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| Authors | Daoming Li, Ying Wang, Chao Chen, Mingbai Zeng, Qianru Li, Qingyun Jia, Xiuli Liu, Yongyue Hou, Chengming Fan, Yuhong Chen, Zanmin Hu |
| Journal | Sheng wu gong cheng xue bao = Chinese journal of biotechnology (Sheng Wu Gong Cheng Xue Bao) Vol. 38 Issue 5 Pg. 1768-1783 (May 25 2022) ISSN: 1872-2075 [Electronic] China |
| PMID | 35611728 (Publication Type: Journal Article) |
| Chemical References |
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