Abstract | AIM: To observe the impact of hormonal treatment (HT) on voiding patterns and renal circadian rhythms in postmenopausal women with and without nocturnal polyuria (NP). MATERIAL AND METHODS: A prospective, observational study was executed at the menopause clinic of a tertiary hospital. HT was based on patients' choice and was in the form of either oral and transdermal oestrogen. Participants completed a 72-hour bladder diary, completed the ICIQ-FLUTS questionnaire, recorded a renal function profile and gave a blood sample. This set of tests was done before and after 3 months of HT. RESULTS: 32 postmenopausal women with a median age of 52.5 (49.3-56.0) years were enroled in this study. Three months of HT resulted in a significant decrease in fluid intake (p < 0.001) and daytime voiding frequency (p = 0.019). No impact on nocturnal parameters was observed. Observations drawn from the questionnaires did not differ between the baseline and three-month assessments. HT led to a disappearance of the circadian rhythm of the diuresis rate and sodium clearance in patients without NP, as no significant difference between daytime and night-time values was observed (diuresis rate p = 0.3; sodium clearance p = 0.08). In patients with NP at baseline, HT did not induce a circadian rhythm of the diuresis rate and sodium clearance (p = 0.2; p = 0.7). In contrast, free water clearance did change to a clear circadian rhythm (p = 0.02). CONCLUSION: HT led to a significant reduction in both fluid intake and daytime frequency. In women without NP, HT led to a disruption of the circadian rhythms of water and salt diuresis. In patients with NP, a limited normalisation of the circadian rhythm of free water clearance was observed after three months of HT. CLINICAL TRIAL REGISTRATION NUMBER FROM CLINICALTRIALS.GOV: NCT04891926.
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Authors | Kim Pauwaert, Elke Bruneel, Erik Van Laecke, Herman Depypere, Karel Everaert, An-Sofie Goessaert |
Journal | Maturitas
(Maturitas)
Vol. 160
Pg. 61-67
(06 2022)
ISSN: 1873-4111 [Electronic] Ireland |
PMID | 35550708
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Circadian Rhythm
- Female
- Humans
- Kidney
(physiology)
- Male
- Nocturia
(drug therapy)
- Pilot Projects
- Polyuria
- Postmenopause
- Prospective Studies
- Sodium
(therapeutic use)
- Urinary Bladder
- Water
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