Nanoparticles have shown great promise in improving
cancer treatment efficacy by changing the intracellular
calcium level through activation of intracellular mechanisms. One of the mechanisms of the killing of the cancerous cell by a nanoparticle is through elevation of the intracellular
calcium level. Evidence accumulated over the past decade indicates a pivotal role for the
IP3 receptor mediated Ca2+ release in the regulation of the cytosolic and the nuclear Ca2+ signals. There have been various studies done suggesting the role of IP3 receptors (IP3R) and IP3 production and degradation in cardiomyocytes. In the present work, we have proposed a three-dimensional unsteady-state mathematical model to describe the mechanism of cardiomyocytes which focuses on evaluation of various parameters that affect these coupled dynamics and elevate the cytosolic
calcium concentration which can be helpful to search for novel
therapies to cure these
malignancies by targeting the complex calcium signaling process in cardiomyocytes. Our study suggests that there are other factors involved in this signaling which can increase the
calcium level, which can help in finding treatment for
cancer. The cytosolic
calcium level may be controlled by IP3 signaling, leak, source influx of
calcium (σ) and maximum production of IP3 (V P). We believe that the proposed model suggests new insight into finding treatment for
cancer in cardiomyocytes through elevation of the cytosolic Ca2+ concentration by various parameters like leak, σ, V P and especially by other complex cell signaling dynamics, namely IP3 dynamics.