ALA-iPDT for follicular occlusion tetrad concomitant with pachyonychia congenital type Ⅱ and ankylosing spondylitis.

Abstract

The follicular occlusion tetrad is a complex dermatologic syndrome which can concomitant with other diseases. The case reported a young male patient suffer from follicular occlusion tetrad (acne conglobata, hidradenitis suppurativa, dissecting cellulitis of the scalp, and pilonidal sinuses) concomitant with pachyonychia congenital type Ⅱ (thickened nails, palmoplantar keratoderma, multiple cysts) and ankylosing spondylitis (lumbago, human leukocyte antigen-B27 positive). The genetic analysis showed the KRT17 gene mutation on exon 1 (c.T284C) supports the diagnosis. Whereupon, a comprehensive therapy scheme of 5-aminolevulinic acid-mediated interstitial photodynamic therapy (ALA-iPDT) combined with surgery offered excellent response. This case reports a rare condition and proposes a therapeutic option that may work.

• Authors: Jia Yan, Guolong Zhang, Caihe Liao, Xiuli Wang, Lei Shi
• Journal: Photodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 39 Pg. 102891 (Sep 2022) ISSN: 1873-1597 [Electronic] Netherlands
• PMID: 35490959 (Publication Type: Case Reports)
• Copyright: Copyright © 2022. Published by Elsevier B.V.

Chemical References

• Aminolevulinic Acid

Topics

• Aminolevulinic Acid (therapeutic use)
• Hidradenitis Suppurativa (diagnosis)
• Humans
• Male
• Nails, Malformed
• Photochemotherapy (methods)
• Spondylitis, Ankylosing (complications, diagnosis, drug therapy)