Abstract | PURPOSE: PATIENTS AND METHODS: A total of 74 patients who started perioperative chemotherapy in Tokushima Municipal Hospital for breast cancer from January 2019 to December 2020 were evaluated for DIP. Patients' and tumors' characteristics, and regimens which caused DIP were investigated. The clinical courses of the DIP patients were also followed up. RESULTS: Twelve of the 74 patients developed DIP. All 12 patients had histories of cyclophosphamide administration;however, the causative drug could not be determined. Ten of the 12 patients were treated with steroids, and all the patients recovered ultimately from the interstitial pneumonia. While chemotherapy was administered in six patients after mild DIP, no relapse of pneumonia was observed. CONCLUSION: DIP during perioperative chemotherapy for breast cancer was resolved with appropriate treatment. Patients were able to resume breast cancer treatment with minimal interruption. J. Med. Invest. 69 : 107-111, February, 2022.
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Authors | Mayumi Ikeuchi, Naoki Hino, Aya Nishisyo, Mariko Aoyama, Miyuki Kanematsu, Hiroaki Inoue, Soichiro Sasa, Tomohiro Inui, Naoki Miyamoto, Kazumasa Okumura, Hiromitsu Takizawa |
Journal | The journal of medical investigation : JMI
(J Med Invest)
Vol. 69
Issue 1.2
Pg. 107-111
( 2022)
ISSN: 1349-6867 [Electronic] Japan |
PMID | 35466130
(Publication Type: Journal Article)
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Topics |
- Breast Neoplasms
(drug therapy, surgery)
- Female
- Humans
- Lung Diseases, Interstitial
(chemically induced)
- Neoplasm Recurrence, Local
- Pneumonia
- Prognosis
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