[Aplastic anemia].

Abstract

In vitro cultures of hemopoietic precursor cells and clinical studies have partly clarified the pathogenesis of aplastic anemia. The defect is located both in the hemopoietic precursor cells and in their microenvironment. The therapeutic possibilities have enormously improved. Allogeneic bone marrow transplantation remains largely limited to young patients with an HLA-identical sibling donor. In our experience successfully transplanted patients are completely cured. Mortality from rejection, graft-versus-host-disease and infection has been markedly reduced. Immune modulating therapy with ALG produces high remission rates but residual defects in hemopoietic precursor cells remain and clonal disorders such as paroxysmal nocturnal hemoglobinuria may ensue. Despite of this ALG is the treatment of choice for patients without an HLA identical sibling donor.

• Authors: B Speck
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 116 Issue 43 Pg. 1467-74 (Oct 25 1986) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Aplastische Anämie.
• PMID: 3538378 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antilymphocyte Serum

Topics

• Anemia, Aplastic (diagnosis, etiology, therapy)
• Antilymphocyte Serum (therapeutic use)
• Bone Marrow Transplantation
• Humans