Abstract | BACKGROUND: OBJECTIVE: The purpose of this study is to clarify the incidence and characteristic of IVIg-induced eczematous eruption in autoimmune neuromuscular disease. METHODS: RESULTS: There are 10 patients (6 CIDP/4 MMN), who had an eczematous skin reaction after IVIg infusion. The frequencies of IVIg-induced eczematous eruption were significantly higher in patients with multifocal acquired demyelinating sensory and motor (MADSAM) and MMN than in patients with GBS, myositis, and MG. In addition, corticosteroids or immunosuppressive drugs had been administrated before IVIg treatment more frequently in patients with myositis and MG than in those with MADSAM and MMN. CONCLUSION: MADSAM or MMN patients had more frequently IVIg-induced eczematous eruption than other autoimmune neuromuscular diseases. Pathophysiology of MADAM and MMN is considered to be cell-mediated immunity against the peripheral nerve and the accumulation of IgG in both epidermis and dermis of the hand after IVIg may induce the infiltration of inflammatory cells around the vessels in the skin, causing eczematous eruption in MADSAM and MMN.
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Authors | Seira Hatake, Fumitaka Shimizu, Masaya Honda, Shiori Takahashi, Michiaki Koga, Kazumi Kimura, Takashi Kanda |
Journal | Rinsho shinkeigaku = Clinical neurology
(Rinsho Shinkeigaku)
Vol. 62
Issue 4
Pg. 267-271
(Apr 27 2022)
ISSN: 1882-0654 [Electronic] Japan |
PMID | 35354723
(Publication Type: Journal Article)
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Chemical References |
- Immunoglobulins, Intravenous
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Topics |
- Autoimmune Diseases
(drug therapy)
- Exanthema
(drug therapy)
- Guillain-Barre Syndrome
(drug therapy)
- Humans
- Immunoglobulins, Intravenous
(adverse effects)
- Myositis
(drug therapy)
- Neuromuscular Diseases
(drug therapy)
- Polyneuropathies
(drug therapy)
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
(therapy)
- Retrospective Studies
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