Abstract | INTRODUCTION: SUBJECTS AND METHODS: RESULTS: The study revealed the high levels of PRL, anti-TPO and anti-TG autoantibodies. Thus, patients were classified into 3 groups by the degree of expected HPRL risk from the antipsychotics used: without expected risk, with low and high expected risks. The correlation analysis detected an inverse significant correlation (R=-0.51; p=0.037) between expected level of drug-associated HPRL risk and actual PRL levels in studied group. At the same time, we detected a positive significant correlation between the levels of PRL and FT4 in the groups (R=0.53; p=0.03). The correlations between the levels of PRL and other parameters such as TSH, FT3, anti-TPO, anti-TG, anti- TSH receptor antibodies were not statistically significant. CONCLUSIONS: HPRL in the group was not associated with taking of antipsychotic drugs with high expected HPRL risk. Yet, a significant positive correlation existed between the levels of PRL and FT4. Hence, in Hashimoto's thyroiditis accompanied with treated mental illness there are some non-iatrogenic stimulants of prolactogenesis. It cannot be ruled out that antipsychotics may interfere with prolactin metabolism, which creates a false effect of a positive correlation between prolactin and free thyroxine levels, in contrast to common HPRL of hypothyroidism.
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Authors | Polina A Sobolevskaia, Leonid P Churilov, Tamara V Fedotkina, Anna Stepochkina, Anastasia Dolina, Anton N Gvozdetckii, Boris V Andreev, Yehuda Shoenfeld |
Journal | Psychiatria Danubina
(Psychiatr Danub)
2021 Spring-Summer
Vol. 33
Issue Suppl 4
Pg. 1106-1112
ISSN: 0353-5053 [Print] Croatia |
PMID | 35354176
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Autoantibodies
- anti-thyroid autoantibodies
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Topics |
- Adult
- Antipsychotic Agents
(adverse effects)
- Autoantibodies
- Hashimoto Disease
(drug therapy, epidemiology)
- Humans
- Hyperprolactinemia
(chemically induced, epidemiology)
- Middle Aged
- Schizophrenia
(drug therapy, epidemiology)
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