Growing evidence supports that
cancer progression is closely associated with the tumor microenvironment and immune evasion. Importantly, recent studies have revealed the crucial roles of epigenetic regulators in shaping the tumor microenvironment and restoring immune recognition.
N6-methyladenosine (m6A) modification, the most prevalent epigenetic modification of mammalian mRNAs, has essential functions in regulating the processing and metabolism of its targeted RNAs, and therefore affects various biological processes including
tumorigenesis and progression. Recent studies have demonstrated the critical functions and molecular mechanisms underlying abnormal
m6A modification in the regulation of
tumor immunity. In this review, we summarize recent research progress in the potential roles of
m6A modification in
tumor immunoregulation, with a special focus on the anti-
tumor processes of immune cells and involvement in immune-associated molecules and pathways. Furthermore, we review current knowledge regarding the close correlation between m6A-related risk signatures and the
tumor immune microenvironment landscape, and we discuss the prognostic value and therapeutic efficacy of
m6A regulators in a variety of
cancer types.