Abstract | BACKGROUND AND OBJECTIVE: METHODS: The literature was searched in different databases, i.e., the National Institute of Health clinical trials registry, PubMed, and the Cochrane library between 2018 to October 2021 using the keywords atogepant, MK-8031, and migraine. Conference abstracts listed in the Cochrane database (includes Embase) and drug information provided by the US Food and Drug Administration (FDA) label were also reviewed. Only English-language clinical trials were included. The authors retrieved 58 articles. Eventually, two randomized, double-blind, multicenter clinical trials involving 1,727 participants and one open-label trial were analyzed. RESULTS: RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE:
Atogepant had a statistically significant change from baseline in monthly migraine days, monthly headache days, and acute medication use days. CONCLUSIONS:
Atogepant seems to be beneficial for migraine prevention, and it may be of more benefit in individuals who do not wish to take the drug as an injection or do not require a prolonged duration of drug effect. However, head-to-head trials with other CGRP antagonists are required to ascertain its place in migraine prevention.
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Authors | Alok Singh, Mahesh Kumar Balasundaram |
Journal | Clinical drug investigation
(Clin Drug Investig)
Vol. 42
Issue 4
Pg. 301-308
(Apr 2022)
ISSN: 1179-1918 [Electronic] New Zealand |
PMID | 35230651
(Publication Type: Systematic Review)
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Copyright | © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG. |
Chemical References |
- Analgesics
- Piperidines
- Pyridines
- Pyrroles
- Spiro Compounds
- atogepant
- Calcitonin Gene-Related Peptide
|
Topics |
- Analgesics
(therapeutic use)
- Calcitonin Gene-Related Peptide
- Double-Blind Method
- Headache
- Humans
- Migraine Disorders
(drug therapy, prevention & control)
- Multicenter Studies as Topic
- Piperidines
- Pyridines
- Pyrroles
- Randomized Controlled Trials as Topic
- Spiro Compounds
- Treatment Outcome
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