Abstract | BACKGROUND: CASE SUMMARY: We report herein the case of a 64-year-old Chinese woman who presented with recurrent PMB. A sex hormone test revealed that her estrogen level was significantly higher than normal, and other causes of hyperestrogenism had been excluded. The patient had undergone four curettage and hysteroscopy procedures in the past 7 years due to recurrent PMB and endometrial hyperplasia. The culprit behind the increase in estrogen level-an ovarian cellular fibroma with estrogenic activity-was eventually found during the fifth operation. CONCLUSION: Ovarian cellular fibromas occur insidiously, and some may have endocrine functions. Postmenopausal patients with recurrent PMB and endometrial thickening observed on ultrasonography are recommended to undergo sex hormone testing while waiting for results regarding the pathology of the endometrium. If the estrogen level remains elevated, the clinician should consider the possibility of an ovarian SCST and follow-up the patient closely, even if the imaging results do not indicate ovarian tumors. Once the tumor is found, it should be removed as soon as possible no matter the size to avoid endometrial lesions due to long-term estrogen stimulation. More studies are needed to confirm whether preventive total hysterectomy with bilateral salpingo-oophorectomy should be recommended for women with recurrent PMB exhibiting elevated estrogen levels, despite the auxiliary examination results not indicating ovarian mass. The physical and psychological burden caused by repeated curettage could be prevented using this technique.
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Authors | Jiao Wang, Qing Yang, Ning-Ning Zhang, Dan-Dan Wang |
Journal | World journal of clinical cases
(World J Clin Cases)
Vol. 10
Issue 1
Pg. 275-282
(Jan 07 2022)
ISSN: 2307-8960 [Print] United States |
PMID | 35071528
(Publication Type: Case Reports)
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Copyright | ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |