The significance of the SDF-1/CXCR4 signaling pathway in the normal development.

Abstract

Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. Therefore, the current review aimed to summarize the related studies that addressed the molecular signature of the SDF-1/CXCR4 pathway and to explain how this axis is involved in normal events.

• Authors: Farzad Sadri, Zohreh Rezaei, Mohammad Fereidouni
• Journal: Molecular biology reports (Mol Biol Rep) Vol. 49 Issue 4 Pg. 3307-3320 (Apr 2022) ISSN: 1573-4978 [Electronic] Netherlands
• PMID: 35067815 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Nature B.V.

Chemical References

• CXCR4 protein, human
• Chemokine CXCL12
• Receptors, CXCR4

Topics

• Cell Movement (physiology)
• Chemokine CXCL12
• Humans
• Neoplasms (metabolism)
• Neovascularization, Pathologic
• Receptors, CXCR4 (genetics, metabolism)
• Signal Transduction