Preparation, biocompatibility, and wound healing effects of O-carboxymethyl chitosan nonwoven fabrics in partial-thickness burn model.
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| Abstract |
This study was aimed at preparing O-carboxymethyl chitosan (CM-CTS) fabrics, and examining the wound healing effects on partial-thickness burn. The functional polysaccharides were produced from chitosan needle-punched nonwovens reacted with chloroacetic acid. Then the biocompatibility and biological functions were evaluated through fibroblast L-929 and SD rats. CM-CTS fabrics were obtained with elongation at break more than 42%, tensile strength reaching 0.65 N/mm2, and water vapor transmission rate about 2600 g/m2∙24 h. Moreover, CM-CTS fabrics could effectively promote the mouse L-929 migration in vitro. CM-CTS fabrics yielded satisfactory results in angiogenesis, collagen deposition, interleukin-6 content, transforming growth factor level and healing rate, which were superior to the positive control and model groups after rats suffering with partial-thickness burn. In conclusion, CM-CTS fabrics possessed proper mechanical properties, air permeability, favorable biocompatibility, acceleration on fibroblasts migration and healing capacity for partial-thickness burn injury, and owned good potential as high-quality wound dressing.
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| Authors | Zhiwen Jiang, Lulu Li, Hui Li, Lixin Xia, Huiwen Hu, Shuo Wang, Chenqi Liu, Jinhua Chi, Yan Yang, Fulai Song, Wanshun Liu, Baoqin Han |
| Journal | Carbohydrate polymers (Carbohydr Polym) Vol. 280 Pg. 119032 (Mar 15 2022) ISSN: 1879-1344 [Electronic] England |
| PMID | 35027134 (Publication Type: Journal Article) |
| Copyright | Copyright © 2021. Published by Elsevier Ltd. |
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