Case Report: Erdafitinib-induced Central Serous Chorioretinopathy.

Abstract

SIGNIFICANCE:

Erdafitinib is the first fibroblast growth factor receptor inhibitor approved by the U.S. Food and Drug Administration in April 2019 for the treatment of locally advanced and unresectable or metastatic urothelial carcinoma. Central serous chorioretinopathy is a common ocular adverse effect requiring frequent monitoring with ophthalmic examination.

PURPOSE:

This study aimed to increase awareness of erdafitinib-induced central serous chorioretinopathy, highlight erdafitinib dose management guidelines, and emphasize the importance of collaborating with oncologists to prevent adverse visual consequences.

CASE REPORT:

An 80-year-old patient with an advanced urothelial cancer with fibroblast growth factor receptor mutations developed central serous chorioretinopathy when he was treated with daily 8 mg of erdafitinib. The erdafitinib-induced central serous chorioretinopathy resolved completely after the discontinuation of erdafitinib. He was then treated with daily 6 mg of erdafitinib and again developed central serous chorioretinopathy, which resolved completely upon discontinuation of the medication. The patient then decided to stop treatment with erdafitinib.

CONCLUSIONS:

Erdafitinib, a potent tyrosine kinase receptor inhibitor of fibroblast growth factor receptors 1 to 4, demonstrates antitumor activity in advanced urothelial carcinoma with fibroblast growth factor receptor mutations with a response rate of approximately 40%. However, central serous chorioretinopathy develops in 25% of patients treated with a daily 8-mg dose of erdafitinib. Although most mild to moderate erdafitinib-induced central serous chorioretinopathies resolve with dose interruption or reduction, occasionally discontinuation of the medication is necessary. Therefore, careful coordination with oncologists is important to assess the impact of erdafitinib on vision, quality of life, and survival prognosis.

• Authors: Richard T Claiborne, Grace L Tsan
• Journal: Optometry and vision science : official publication of the American Academy of Optometry (Optom Vis Sci) Vol. 99 Issue 1 Pg. 88-92 (01 01 2022) ISSN: 1538-9235 [Electronic] United States
• PMID: 34882600 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2021 American Academy of Optometry.

Chemical References

• Protein Kinase Inhibitors
• Pyrazoles
• Quinoxalines
• Receptors, Fibroblast Growth Factor
• erdafitinib

Topics

• Aged, 80 and over
• Carcinoma, Transitional Cell
• Central Serous Chorioretinopathy (chemically induced, diagnosis, drug therapy)
• Female
• Humans
• Male
• Protein Kinase Inhibitors (adverse effects)
• Pyrazoles
• Quality of Life
• Quinoxalines
• Receptors, Fibroblast Growth Factor (genetics, therapeutic use)
• United States
• Urinary Bladder Neoplasms (pathology)