Abstract | BACKGROUND: METHODS: A retrospective cohort study of pregnant women with HIV-1 on ART. The primary outcome was incidence of excess gestational weight gain. Treatment effects were estimated by ART regimen type using log-linear models for relative risk (RR), adjusting for prepregnancy BMI and presence of detectable viral load at baseline. RESULTS: Three hundred three pregnant women were included in the analysis. Baseline characteristics, including prepregnancy BMI, viral load at prenatal care entry, and gestational age at delivery were similar by ART, including 53% of the entire cohort had initiated ART before pregnancy (P = nonsignificant). Excess gestational weight gain occurred in 29% of the cohort. Compared with non- integrase strand transfer inhibitor (-INSTI) or tenofovir alafenamide fumarate (TAF)-exposed persons, receipt of INSTI+TAF showed a 1.7-fold increased RR of excess gestational weight gain (95% CI: 1.18-2.68; P < .01), while women who received tenofovir disoproxil fumarate had a 0.64-fold decreased RR (95% CI: .41-.99; P = .047) of excess gestational weight gain. INSTI alone was not significantly associated with excess weight gain in this population. The effect of TAF without INSTI could not be inferred from our data. There was no difference in neonatal, obstetric, or maternal outcomes between the groups. CONCLUSIONS: Pregnant women receiving ART with a combined regimen of INSTI and TAF have increased risk of excess gestational weight gain.
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Authors | Naima T Joseph, Glen A Satten, Rachel E Williams, Lisa B Haddad, Denise J Jamieson, Anandi N Sheth, Martina L Badell |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 75
Issue 4
Pg. 665-672
(09 10 2022)
ISSN: 1537-6591 [Electronic] United States |
PMID | 34864949
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]. |
Chemical References |
- Anti-Retroviral Agents
- Adenine
|
Topics |
- Adenine
(therapeutic use)
- Anti-Retroviral Agents
(therapeutic use)
- Body Mass Index
- Female
- Gestational Weight Gain
- HIV Infections
(drug therapy)
- HIV-1
- Humans
- Infant, Newborn
- Pregnancy
- Pregnancy Outcome
(epidemiology)
- Retrospective Studies
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