Abstract | OBJECTIVE: METHODS: A systematic search was conducted using the following databases: PubMed, MEDLINE with Full Text, CINAHL complete, Cochrane database of systematic reviews, Cochrane methodology register, MasterFILE Premier, APA PsychArticles, APA PsychInfo, APA PsycBooks, APA PsycTests, TRIP, Nursing and Allied Health. The quality of each retained study was assessed using appropriate risk of bias tools based on study design. RESULTS: The initial search resulted in 1422 articles from which 22 articles were included for qualitative synthesis. Study designs ranged from case reports to double blind, placebo controlled randomized trials and was interpreted uniquely based on study design. Acetazolamide was effective in improving some PPD outcomes. Fluoxetine at high doses was effective in reducing fluid intake and polydipsia. Other medications included in this review performed equivocally for reduction of numerous parameters evaluating PPD. CONCLUSION: No one drug appeared to be the most efficacious; however, some did show promise in specific populations. Those in need of pharmacotherapeutic options for PPD may consider one of the included agents to assist with co-morbid state. Further high-quality research is needed to provide better treatment guidance for PPD.
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Authors | Thomas H Havens, Gaetano Innamorato, Eric C Nemec 2nd |
Journal | Journal of psychosomatic research
(J Psychosom Res)
Vol. 152
Pg. 110674
(Nov 20 2021)
ISSN: 1879-1360 [Electronic] England |
PMID | 34856427
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |