Abstract |
A piezo-photocatalytic therapy based on thermally treated natural sphalerite nanosheet (NSH700 NS) heterojunction was applied to efficiently induce intracellular ROS burst and apoptosis of cancer cells. Upon ultrasound and laser irradiation, the formation of a polarized electric field and band bending of NSH700 NSs allow the directional separation of charges both in the bulk and their interface, thereby minimizing the probability of charge recombination. The piezo-photocatalytic effect leads to an efficient catalytic performance, exhibiting high-performance superoxide radical (˙O2-) and hydroxyl radical (˙OH) generation and glutathione (GSH) depletion, which results in a intracellular ROS burst-triggered apoptosis of cancer cells both in vitro and in vivo.
|
Authors | Yong Kang, Lei Lei, Chunfeng Zhu, Hanjie Zhang, Lin Mei, Xiaoyuan Ji |
Journal | Materials horizons
(Mater Horiz)
Vol. 8
Issue 8
Pg. 2273-2285
(08 01 2021)
ISSN: 2051-6355 [Electronic] England |
PMID | 34846431
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Reactive Oxygen Species
- Superoxides
- Glutathione
|
Topics |
- Apoptosis
- Catalysis
- Glutathione
- Neoplasms
(therapy)
- Reactive Oxygen Species
- Superoxides
|