Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial-mesenchymal transition in ARPE-19 cells.

Abstract

OBJECTIVE:

Epithelial-mesenchymal transition (EMT) is involved in the development of proliferative vitreoretinopathy (PVR) and subsequent fibrosis. Previously, we demonstrated that placental extract ameliorates fibrosis in a mouse model of non-alcoholic steatohepatitis. In this study, we evaluated whether placental extract influences EMT and fibrosis through cytokine-induced EMT in the retinal pigment epithelial cells, in vitro.

RESULTS:

Placental extract did not inhibit EMT, but it suppressed excessive mesenchymal reactions and the subsequent fibrosis. These results suggest that placental extract effectively ameliorates EMT-associated fibrosis in PVR. This beneficial effect could be partially attributed to the suppression of excessive mesenchymal reactions.

• Authors: Kyoko Igarashi, Koji Sugimoto, Eiichi Hirano
• Journal: BMC research notes (BMC Res Notes) Vol. 14 Issue 1 Pg. 407 (Nov 02 2021) ISSN: 1756-0500 [Electronic] England
• PMID: 34727968 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s).

Chemical References

• Placental Extracts
• Transforming Growth Factor beta
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Epithelial-Mesenchymal Transition
• Female
• Fibrosis
• Mice
• Placenta
• Placental Extracts
• Pregnancy
• Retinal Pigment Epithelium
• Transforming Growth Factor beta
• Tumor Necrosis Factor-alpha