Allulose Attenuated Age-Associated Sarcopenia via Regulating IGF-1 and Myostatin in Aged Mice.

Abstract

SCOPE:

Allulose is shown to increase the muscle weight in diet-induced obese mice. However, there are no studies on the effects of allulose in age-associated sarcopenia. This study aims to elucidate the mechanisms of action for allulose in age associated by analyzing the transcriptional patterns in aged mice.

METHODS AND RESULTS:

The 48-week-old mice are fed with AIN-93diet containing allulose for 12 weeks. Allulose supplementation increases the muscle mass and grip strength in aged mice. Allulose increases the insulin-like growth factor 1 (IGF-1) and its downstream factor expressions which 40 are related protein synthesis, while inhibits the myostatin expression related protein degradation. In mRNA-seq analysis, allulose supplementation significantly decreases in Adiponectin, Adipsin, cell death inducing DFFA like effector (CIDEC), Haptoglobin, Neuroglobin, and stearoyl-CoA desaturase-1 (SCD1) and increases in cytokine-inducible SH2-containing protein (CISH) and ceramide synthase 1 (CerS1) that are regulate protein turn over in gastrocnemius. Also, allulose alleviates autophagy in muscle with regulated mammalian target of rapamycin (mTOR) signaling pathway and increases the anti-oxidant enzyme activity.

CONCLUSION:

These findings suggest that allulose improves the age-associated sarcopenia with enhancing antioxidant properties by altering mRNA and protein expression.

• Authors: Ji-Eun Kim, Eun-Young Kwon, Youngji Han
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 66 Issue 1 Pg. e2100549 (01 2022) ISSN: 1613-4133 [Electronic] Germany
• PMID: 34710274 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 Wiley-VCH GmbH.

Chemical References

• Myostatin
• psicose
• Fructose
• Insulin-Like Growth Factor I

Topics

• Animals
• Fructose
• Insulin-Like Growth Factor I (genetics, metabolism)
• Mammals
• Mice
• Mice, Obese
• Muscle, Skeletal (metabolism)
• Myostatin (genetics, metabolism, pharmacology)
• Sarcopenia (drug therapy, metabolism, prevention & control)