Neuroglobin

03/01/2013 - "In a recent study, neuroglobin was ubiquitously expressed and up-regulated following stroke in the human brain. "
01/03/2020 - "In this work, these nanoparticles have been used to carry neuroglobin through the bloodstream to the nerve cells in rats submitted to stroke. "
01/03/2020 - "Hyaluronate Nanoparticles as a Delivery System to Carry Neuroglobin to the Brain after Stroke."
08/24/2015 - "These findings indicate a potential control model for the anti-apoptotic activity of neuroglobin, under likely physiological conditions, whereby, in normoxic conditions, the anti-apoptotic activity of neuroglobin is maintained at a low level, whilst immediately a transition occurs to a hypoxic situation, as might arise during stroke, the anti-apoptotic activity is drastically increased. "
06/01/2004 - "Neuroglobin may promote neuronal survival under hypoxic conditions as they occur, for example, in stroke."

09/01/2011 - "Over the last decade, numerous studies have suggested that neuroglobin is able to protect against the effects of ischemia. "
02/01/2014 - "Neuroglobin plays an important role in neuronal death upon ischemia and oxidative stress. "
01/01/2012 - "This suggests no selective sparing of neuroglobin expressing neurons in ischemia. "
11/01/2010 - "Neuroglobin protects neurons against oxidative stress in global ischemia."
07/01/2010 - "[The neuroglobin expression when retinal ganglion cells death in acute rats' retina ischemia]."

01/01/2020 - "Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology."
01/01/2018 - "Neuroglobin (Ngb) has been reported to be increased in early and moderately advanced Alzheimer's disease (AD) stages but declined in the severe stage. "
01/01/2017 - "Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late-stage AD. "
01/01/2013 - "We conclude that, as in transgenic mouse models, neuroglobin may influence the course of clinical Alzheimer's disease. "
01/01/2013 - "Neuroglobin levels were increased in early and moderately advanced Alzheimer's disease compared to controls, but declined to control levels in severe disease. "

01/01/2021 - "The study determined Neuroglobin (Ngb) and Hypoxia-inducible factor (HIF-1α) expression in the telencephalon of yak and cattle, and compare the expression and distribution pattern of Ngb and HIF-1α in the two animals. "
01/01/2021 - "The study examined the expression of Neuroglobin (Ngb) and Hypoxia-inducible factor-1α (Hif-1α) in adult and young yak brain tissues, and provided researchers with meaningful insight into the anatomy, physiology, and biochemistry of this mammal. "
01/20/2016 - "Previous studies suggested that the neuroglobin GLB-5 genetically interacts with GCY-35, and that the inhibitory effect of GLB-5 on GCY-35 function is necessary for fast recovery from prolonged hypoxia. "
08/24/2015 - "Previous studies identifying the potential anti-apoptotic role of neuroglobin raise the question as to how cells might employ neuroglobin to avoid the apoptotic impact of acute hypoxia whilst also avoiding chronic enhancement of tumour formation. "
07/01/2004 - "Based on this high-resolution structure, further structure-function studies can be planned to elucidate the role of neuroglobin in physiological responses to hypoxia."

08/01/2013 - "The aim of the present study was to uncover the mechanism underlying the neuroprotection of Hemin‑mediated neuroglobin (Ngb) in an in vivo model of brain injury. "
01/01/2016 - "Since neuroglobin promotes neuronal survival, its increased expression in astrocytes after brain injury may represent an endogenous neuroprotective mechanism. "
01/01/2016 - "After brain injury, neuroglobin expression is induced in astrocytes. "
08/01/2013 - "Hemin‑mediated neuroglobin induction exerts neuroprotection following ischemic brain injury through PI3K/Akt signaling."
08/01/2013 - "Neuroglobin (Ngb) is an endogenous neuroprotective molecule against hypoxic/ischemic brain injury, but the underlying mechanisms remain largely undefined. "