Abstract | BACKGROUND: Nonimmediate (delayed)- allergic reactions to penicillins are common and some of them can be life-threatening. The genetic factors influencing these reactions are unknown/poorly known/poorly understood. We assessed the genetic predictors of a delayed penicillin allergy that cover the HLA loci. METHODS: RESULTS: The two alleles DRB3*02:02:01:02 and DRB3*02:02:01:01 were reported in twenty cases with delayed reactions (83%) and ten cases with immediate reactions (50%), but not in the Allele Frequency Net Database. Bearing at least one of the two alleles increased the risk of delayed reactions compared to immediate reactions, with an OR of 8.88 (95% CI, 3.37-23.32; p < .0001). The haplotype ( ACAA) from rs9268835, rs6923504, rs6903608, and rs9268838 genetic variants of the HLA-DRB3 genomic region was significantly associated with an increased risk of delayed hypersensitivity to penicillins (OR, 1.7; 95% CI: 1.06-1.92; p = .001), but not immediate hypersensitivity. CONCLUSION: We showed that the HLA-DRB3 locus is strongly associated with an increased risk of delayed penicillin hypersensitivity, at least in Southwestern Europe. The determination of HLA-DRB3*02:02 alleles in the risk management of severe delayed hypersensitivity to penicillins should be evaluated further in larger population samples of different origins.
|
Authors | Antonino Romano, Abderrahim Oussalah, Celine Chery, Rosa-Maria Guéant-Rodriguez, Francesco Gaeta, Jose-Antonio Cornejo-Garcia, Pierre Rouyer, Thomas Josse, Cristobalina Mayorga, Maria-Jose Torres, Jean-Louis Guéant |
Journal | Allergy
(Allergy)
Vol. 77
Issue 6
Pg. 1827-1834
(06 2022)
ISSN: 1398-9995 [Electronic] Denmark |
PMID | 34687232
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. |
Chemical References |
- HLA-DRB3 Chains
- Penicillins
|
Topics |
- Alleles
- Drug Hypersensitivity
(epidemiology)
- Genotype
- HLA-DRB3 Chains
(genetics)
- High-Throughput Nucleotide Sequencing
- Humans
- Hypersensitivity, Delayed
(chemically induced, genetics)
- Hypersensitivity, Immediate
(complications)
- Penicillins
(adverse effects)
|