DEAD-Box RNA Helicases and Genome Stability.

Abstract

DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box RNA helicase family proteins including DDX1, DDX3X, DDX5, DDX19, DDX21, DDX39B, and DDX41. For each helicase, we have reviewed evidence supporting their role in protecting the genome and their suggested mechanisms. Such helicases regulate the expression of factors promoting genomic stability, prevent DNA damage, and can participate directly in the response and repair of DNA damage. Finally, we summarized the pathological and therapeutic relationship between DEAD-box RNA helicases and cancer with respect to their novel role in genome stability.

• Authors: Michael Cargill, Rasika Venkataraman, Stanley Lee
• Journal: Genes (Genes (Basel)) Vol. 12 Issue 10 (09 23 2021) ISSN: 2073-4425 [Electronic] Switzerland
• PMID: 34680866 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Nucleocytoplasmic Transport Proteins
• RNA
• DDX1 protein, human
• DDX19B protein, human
• DDX21 protein, human
• DDX39B protein, human
• DDX3X protein, human
• DDX41 protein, human
• Ddx5 protein, human
• DEAD-box RNA Helicases

Topics

• DEAD-box RNA Helicases (classification, genetics)
• DNA Repair (genetics)
• Genomic Instability (genetics)
• Humans
• Neoplasms (genetics)
• Nucleocytoplasmic Transport Proteins (genetics)
• RNA (genetics)