Coacervate-Based Instant and Repeatable Underwater Adhesive with Anticancer and Antibacterial Properties.

Abstract

Underwater adhesion is a great challenge for the development of adhesives as the attractive interfacial intermolecular interactions are usually weakened by the surface hydration layer. The coacervation process of sessile organisms like marine mussels and sandcastle worms has inspired substantial research interest in the fabrication of long-lasting underwater adhesives, but they generally suffer from time-consuming curing triggered by surrounding environmental changes and cannot reserve the adhesiveness once damaged. Herein, an instant and repeatable underwater adhesive was developed based on the coacervation of tannic acid (TA) and poly(ethylene glycol)77-b-poly(propylene glycol)29-b-poly(ethylene glycol)77 (PEG-PPG-PEG, F68), which was driven by hydrogen-bonding interaction, and the hydrophobic cores of F68 micelles offered an additional cross-linking to enhance the mechanical properties. The TA-F68 coacervates could be facilely painted on different substrates, exhibiting robust and instant underwater adhesion (with adhesion strength up to 1.1 MPa on porcine skin) and excellent repeatability (at least 1000 cycles), superior to the previously reported coacervates. Due to the biological activities of TA, the underwater adhesive displayed innate anticancer and antibacterial properties against different types of cancer cells and bacteria, showing great potential for diverse biomedical applications, such as injectable drug carriers, tissue glues, and wound dressings.

• Authors: Qiongyao Peng, Qiuqiu Wu, Jingsi Chen, Tao Wang, Meng Wu, Diling Yang, Xuwen Peng, Jifang Liu, Hao Zhang, Hongbo Zeng
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 13 Issue 40 Pg. 48239-48251 (Oct 13 2021) ISSN: 1944-8252 [Electronic] United States
• PMID: 34601867 (Publication Type: Journal Article)

Chemical References

• Adhesives
• Anti-Bacterial Agents
• Antineoplastic Agents
• Tannins
• Water
• Poloxamer

Topics

• Adhesiveness
• Adhesives (chemistry, pharmacology)
• Animals
• Anti-Bacterial Agents (chemistry, pharmacology)
• Antineoplastic Agents (chemistry, pharmacology)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Escherichia coli (drug effects)
• Humans
• Hydrogen Bonding
• Hydrophobic and Hydrophilic Interactions
• Microbial Sensitivity Tests
• Poloxamer (chemistry, pharmacology)
• Skin (metabolism)
• Staphylococcus aureus (drug effects)
• Swine
• Tannins (chemistry, pharmacology)
• Water (chemistry)