Biomimetic nanoparticles loading with gamabutolin-indomethacin for chemo/photothermal therapy of cervical cancer and anti-inflammation.

Abstract

A pro-nanodrug combinational strategy for efficient cervical cancer therapy with intrinsic tumor microenvironment (TME)-responsive elements and low side effects is highly desired. Here, a pro-nanodrug complexes with GSH and NIR responsive manner is reported to boost gamabufotalin induced chemo-photothermal therapy with the assistance of reprogrammed TME by indomethacin. In addition, hybrid cell membrane was used to endow nanocomplexes with the prolonging circulation time and high accumulation of drug at tumor tissue. Indomethacin activated by the high level GSH can attenuate tumor inflammation microenvironment triggered by PTT and sensitize tumor cells to gamabufotalin through inhibiting PGE2 secretion. The released low-dose gamabufotalin with low side effects can efficiently kill tumor cells by ROS production and COX-2 low expression. In vitro and in vivo assays demonstrated that strong anti-tumor activity of nanocomplexes in tumor-bearing mice through chemo-photothermal therapy, which was reflected by the eradication of cervical tumor and significant extension of survival time of mice.

• Authors: Chang Xiao, Chunyi Tong, Jialong Fan, Zhou Wang, Qian Xie, Ying Long, Peidong You, Wei Wang, Bin Liu
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 339 Pg. 259-273 (11 10 2021) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 34597747 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Doxorubicin
• Indomethacin

Topics

• Animals
• Biomimetics
• Doxorubicin
• Female
• Humans
• Hyperthermia, Induced
• Indomethacin
• Mice
• Nanoparticles
• Phototherapy
• Photothermal Therapy
• Tumor Microenvironment
• Uterine Cervical Neoplasms (therapy)