Molecular Imaging with 18F-FDG PET/CT and 99mTc-MIBI SPECT/CT in Osteitis Fibrosa Cystica Generalisata.

Abstract

Benign so-called "brown tumors" secondary to hyperparathyroidism are a rare diagnostic pitfall due to their impressively malignant-like character in various imaging modalities. We present the case of a 65-year-old male patient with multiple unclear osteolytic lesions on prior imaging suspicious for metastatic malignant disease. Eventually, findings of 18F-FDG PET/CT staging and 99mTc-MIBI scintigraphy resulted in revision of the initially suspected malignant diagnosis. This case illustrates how molecular imaging findings non-invasively corroborate the correct diagnosis of osteitis fibrosa cystica generalisata with the formation of multiple benign brown tumors.

• Authors: Adrien Holzgreve, Matthias P Fabritius, Thomas Knösel, Lena M Mittlmeier, Johannes Rübenthaler, Reinhold Tiling, Christoph J Auernhammer, Peter Bartenstein, Marcus Unterrainer
• Journal: Diagnostics (Basel, Switzerland) (Diagnostics (Basel)) Vol. 11 Issue 8 (Jul 28 2021) ISSN: 2075-4418 [Print] Switzerland
• PMID: 34441290 (Publication Type: Journal Article)