New perspectives arise in the therapeutic practice for
cancer, with the objective to not only treat patients, but also improve their quality of life. Guarana, a plant from Brazilian Amazon presents a wide range of pharmacological actions. This study evaluated the effect of Guarana (Paullinia cupana) extract, pure and dry Guarana (PC-18) extract and
magnesium chloride (MgCl2) in mice of the Balb/c strain inoculated with the Ehrlich
tumor regarding gene expression of inflammatory markers transforming growth factor-β1 and
tumor necrosis factor alpha and oxidative stress (OS) and
fatigue,
superoxide dismutase,
catalase, and
glutathione peroxidase 4 and analyzed myelotoxicity and hepatotoxicity. After
euthanasia, blood was collected to analyze the complete blood count and measured the levels of liver
enzymes (
alanine aminotransferase and
aspartate aminotransferase). Hepatoprotective actions of the
crude extract of P. cupana and PC-18 extract were noticed. The PC-18 and
MgCl2 group showed the best result regarding animal welfare. There were no associations between compounds and gene expression regarding
fatigue and OS. PC-18 reduced the
tumor and may have an antitumor action. The
crude extract of Guarana presented hepatoprotective action.