Abstract | BACKGROUND: CASE: The patient was a 63-year-old man who had a history of heavy smoking. He quit smoking when he was diagnosed with glottic squamous cell carcinoma. The RT dose was 63 Gy, delivered in 28 fractions with the three-dimensional conventional RT technique for the larynx. After RT completion, the initial treatment response was complete response. He then underwent follow-up examinations. At 13 months after RT, the patient resumed smoking. At 2 months after resuming smoking, he had severe sore throat and hoarseness. Laryngoscopy revealed a large tumor in the glottis. Surgical excision was performed, and the patient was histologically diagnosed with RLN, as late toxicity without cancer recurrence. At 3 weeks postoperatively, the patient had dyspnea, and laryngoscopy revealed total laryngeal paralysis. Thus, he underwent an emergent tracheostomy. The administration of steroids affected RLN, and laryngeal paralysis gradually improved. CONCLUSIONS: This case suggests that smoking may have the potential to induce RLN after RT. Moreover, continuing smoking cessation is significantly important for patients with glottic cancer who receive RT. Rather than leaving smoking cessation up to the patient, it would be necessary for clinicians to actively intervene to help patients continue their effort to quit smoking.
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Authors | Yoshiaki Takagawa, Sachiko Izumi, Minoru Aoki, Yuka Umeda, Kazuto Ochiai, Junko Kumada, Muneo Nakaya, Yuichiro Kadomatsu, Shingo Itagaki, Midori Kita |
Journal | Cancer reports (Hoboken, N.J.)
(Cancer Rep (Hoboken))
Vol. 5
Issue 7
Pg. e1530
(07 2022)
ISSN: 2573-8348 [Electronic] United States |
PMID | 34396712
(Publication Type: Case Reports)
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Copyright | © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. |
Topics |
- Glottis
(pathology, surgery)
- Head and Neck Neoplasms
(pathology)
- Humans
- Laryngeal Neoplasms
(etiology, radiotherapy, surgery)
- Larynx
(pathology)
- Male
- Middle Aged
- Necrosis
(pathology)
- Neoplasm Recurrence, Local
(pathology)
- Radiation Injuries
- Smoking
(adverse effects)
- Squamous Cell Carcinoma of Head and Neck
(pathology, radiotherapy)
- Vocal Cord Paralysis
(pathology)
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