Abstract | BACKGROUND: METHODS: RESULTS: Growth of 8505C in low- glucose medium with 3-bromopyruvate decreased cell proliferation by 89%, migration by 44%, and invasion by 73% (P < .001 for all) compared with high glucose. Animals concomitantly receiving a ketogenic diet and 3-bromopyruvate exhibited smaller tumor volumes (P = .03), slower tumor growth rates (P = .01), and improved overall survival (P = .006) compared with standard-diet control subjects. Monotherapy with a ketogenic diet or 3-bromopyruvate alone did not reduce tumor size or increase survival over the standard-diet control group. CONCLUSION:
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Authors | Bixiao Zhao, Abha Aggarwal, Jessica A Marshall, Justine A Barletta, Marie F Kijewski, Jochen H Lorch, Matthew A Nehs |
Journal | Surgery
(Surgery)
Vol. 171
Issue 1
Pg. 227-234
(01 2022)
ISSN: 1532-7361 [Electronic] United States |
PMID | 34334212
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Combined Modality Therapy
(methods)
- Diet, Ketogenic
- Female
- Humans
- Mice
- Pyruvates
(pharmacology, therapeutic use)
- Thyroid Carcinoma, Anaplastic
(pathology, therapy)
- Thyroid Neoplasms
(pathology, therapy)
- Tumor Burden
(drug effects)
- Warburg Effect, Oncologic
(drug effects)
- Xenograft Model Antitumor Assays
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