The Effect of Curcumin Supplemsentation on Anthropometric Indices in Overweight and Obese Individuals: A Systematic Review of Randomized Controlled Trials.

Abstract

BACKGROUND:

Curcumin is an active molecule present in turmeric and is the main therapeutic compound. There is growing evidence that curcumin could affect various anthropometric indices. We performed a systematic review to evaluate the efficacy of curcumin supplementation on anthropometric indices in obese and overweight individuals.

METHODS:

A comprehensive search was conducted in PubMed, Scopus, Web of Science, and Google Scholar from inception up to February 2020 to identify randomized controlled trials investigating the effect of curcumin supplementation on anthropometric indices including body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), arm circumference (AC), waist-hip ratio (WHR), total body fat (TBF), and visceral fat (VF) in obese and overweight individuals. The Jadad scale was used to assess the quality of the included studies.

RESULT:

Twenty-eight randomized controlled trials, comprising 2168 participants, were included in the systematic review. The results of 16 papers indicated that curcumin reduced at least one of the anthropometric indices among individuals with a BMI ≥ 25 kg/m2. Nevertheless, 12 articles showed that curcumin supplementation was not effective in any of the measured anthropometric factors. The included trials exhibited substantial heterogeneity in terms of the treatment protocol, follow-up duration, curcumin dosage, and background diseases of the participants.

CONCLUSION:

Clinical trials that have independently examined the effects of curcumin in obese or overweight individuals are limited. However, available studies indicate that curcumin has beneficial impacts on various anthropometric indices. Further trials with longer duration of interventions are needed to confirm these findings.

• Authors: Zahra Safari, Mohammad Bagherniya, Gholamreza Askari, Thozhukat Sathyapalan, Amirhossein Sahebkar
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 1291 Pg. 121-137 ( 2021) ISSN: 0065-2598 [Print] United States
• PMID: 34331687 (Publication Type: Journal Article, Systematic Review)
• Copyright: © 2021. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.

Chemical References

• Curcumin

Topics

• Body Mass Index
• Body Weight
• Curcumin (therapeutic use)
• Dietary Supplements
• Humans
• Obesity (drug therapy)
• Overweight (drug therapy)
• Randomized Controlled Trials as Topic