Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats.

Abstract

In the present study, we aimed to investigate the effect of individual and combined treatment of sinapic acid (SA) and ellagic acid (EA) in streptozotocin (STZ)-induced diabetic rats. Rats were divided into eight groups (n = 7): Normal Control, Diabetic Control, Diabetic + Sinapic Acid, Diabetic + Ellagic Acid, Diabetic + Sinapic Acid + Ellagic Acid, Sinapic Acid, Ellagic Acid and Sinapic Acid + Ellagic Acid. Diabetic groups were injected with a single dose of 50 mg/kg STZ intraperitoneally. Rats received 20 mg/kg/day SA and 50 mg/kg/day EA intragastrically for 28 days. The numerical density of immunopositive β-cells and volume density of pancreatic islets were calculated. Additionally, glucose and insulin levels in serum, MDA, GSH, and CAT levels of pancreatic tissue were measured. While serum glucose levels increased, serum insulin levels decreased in STZ-induced diabetic rats. But these changes in glucose and insulin were restored by individual and combined treatments of SA and EA. Also, individual and combined treatments of SA and EA increased insulin expression of β-cells in STZ-induced diabetic rats. Moreover, these compounds improved deteriorating oxidative stress parameters in STZ-induced diabetic rats. Our study indicates that SA and EA, especially their combined treatments, can be used as an antihyperglycemic agent in diabetes.

• Authors: Fikret Altındağ, Murat Çetin Rağbetli, Uğur Özdek, Necat Koyun, Jamal Khalid Ismael Alhalboosi, Sadi Elasan
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 156 Pg. 112443 (Oct 2021) ISSN: 1873-6351 [Electronic] England
• PMID: 34329744 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Coumaric Acids
• Hypoglycemic Agents
• Insulin
• Ellagic Acid
• Streptozocin
• sinapinic acid

Topics

• Animals
• Body Weight (drug effects)
• Coumaric Acids (administration & dosage, pharmacology, therapeutic use)
• Diabetes Mellitus, Experimental (drug therapy, metabolism)
• Drug Therapy, Combination
• Ellagic Acid (administration & dosage, pharmacology, therapeutic use)
• Female
• Hyperglycemia (drug therapy, metabolism)
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Oxidative Stress
• Rats
• Rats, Wistar
• Streptozocin