Intralesional Hyaluronic Acid Injection for Chondrodermatitis Nodularis Helicis: A Novel Treatment for Rapid Relief of Pain and Healing of Ulcerations.

Abstract

BACKGROUND:

Chondrodermatitis nodularis helicis (CNH) is a common chronic condition characterized by a tender nodule on the helix or antihelix of the ear which may or may not have accompanying crusting, scaling, or ulceration and that is often difficult to treat.

OBJECTIVE:

Develop an easy, effective, and durable treatment to reduce the pain and clinical signs including ulcerations associated with CNH using injectable hyaluronic acid (HA).

MATERIALS AND METHODS:

Twenty-four patients were injected and followed up in 2 to 4 weeks intervals using 0.2 to 0.3 mL of various HA with a high G-Prime.

RESULTS:

Injectable HA significantly improved the symptoms and also the clinical appearance of all patients treated after 1 or 2 injections except 1 patient. Extrusion of the material through a preexisting ulcer usually required a second follow-up injection 2 weeks later. No adverse events were noted with the injections other than the intentional visible bulging of the injected region with HA.

CONCLUSION:

Injectable HA provides almost immediate relief from the discomfort of CNH in most cases in less than 1 or 2 weeks, significantly improves the clinical appearance over time and resolves accompanying ulcerations.

• Authors: Wayne Carey
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 47 Issue 3 Pg. 373-376 (03 01 2021) ISSN: 1524-4725 [Electronic] United States
• PMID: 34328289 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Adjuvants, Immunologic
• Hyaluronic Acid

Topics

• Adjuvants, Immunologic (administration & dosage)
• Adult
• Aged
• Aged, 80 and over
• Cartilage Diseases (complications, diagnosis, drug therapy)
• Chronic Disease
• Dermatitis (complications, diagnosis, drug therapy)
• Ear Auricle
• Ear Diseases (complications, diagnosis, drug therapy)
• Female
• Follow-Up Studies
• Humans
• Hyaluronic Acid (administration & dosage)
• Injections, Intralesional
• Male
• Middle Aged
• Pain (drug therapy, etiology)
• Wound Healing (drug effects)