Role of VLDL receptor in atherogenesis.

Abstract

PURPOSE OF REVIEW:

My group previously discovered and characterized the rabbit and human VLDL receptors. For more than 30 years, I have focused on research regarding the functions of VLDL receptors in the fields of lipoprotein metabolism and atherogenesis. In this review, I introduce the roles of VLDL receptors in lipoprotein metabolism under physiological conditions and in atherogenesis under nonphysiological conditions.

RECENT FINDINGS:

I propose that the VLDL receptor plays key roles in the metabolism of postprandial remnant lipoproteins in concert with lipoprotein lipase (LPL). Furthermore, I propound a new mechanism for macrophage foam cell formation via VLDL receptors by remnant lipoproteins and lipoprotein(a) [Lp(a)] in addition to scavenger receptor pathways.

SUMMARY:

The VLDL receptor is a so-called macrophage β-VLDL receptor, which is involved in macrophage foam cell formation by remnant lipoproteins. Furthermore, Lp(a) is a VLDL receptor ligand and is directly taken up through macrophage VLDL receptors for macrophage foam cell formation. Additionally, the roles of VLDL receptors in atherogenesis are canvassed.

SUPPLEMENTARY VIDEO ABSTRACT:

http://links.lww.com/COL/A21.

• Authors: Sadao Takahashi
• Journal: Current opinion in lipidology (Curr Opin Lipidol) Vol. 32 Issue 4 Pg. 219-225 (08 01 2021) ISSN: 1473-6535 [Electronic] England
• PMID: 34227576 (Publication Type: Journal Article, Review, Video-Audio Media)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Lipoprotein(a)
• Lipoproteins, VLDL
• Receptors, LDL
• VLDL receptor

Topics

• Animals
• Atherosclerosis
• Foam Cells
• Humans
• Lipoprotein(a)
• Lipoproteins, VLDL
• Rabbits
• Receptors, LDL