Cardiooncology-dealing with modern drug treatment, long-term complications, and cancer survivorship.

Abstract

Modern treatment strategies have improved prognosis and survival of patients with malignant diseases. The key components of tumor treatment are conventional chemotherapy, radiotherapy, targeted therapies, and immunotherapy. Cardiovascular side-effects may occur in the early phase of tumor therapy or even decades later. Therefore, knowledge and awareness of acute and long-lasting cardiac side effects of anti-cancer therapies are essential. Cardiotoxicity impairs quality of life and overall survival. The new cardiologic subspecialty 'cardio-oncology' deals with the different cardiovascular problems arising from tumor treatment and the relationship between cancer and heart diseases. Early detection and treatment of cardiotoxicity is of crucial importance. A detailed cardiac assessment of patients prior to administration of cardiotoxic agents, during and after treatment should be performed in all patients. The current review focusses on acute and long-term cardiotoxic side effects of classical cytotoxic and selected modern drug treatments such as immune checkpoint inhibitors and discusses strategies for the diagnosis of treatment-related adverse cardiovascular effects in cancer patients.

• Authors: Claudia de Wall, Johann Bauersachs, Dominik Berliner
• Journal: Clinical & experimental metastasis (Clin Exp Metastasis) Vol. 38 Issue 4 Pg. 361-371 (08 2021) ISSN: 1573-7276 [Electronic] Netherlands
• PMID: 34117981 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021. The Author(s).

Chemical References

• Antineoplastic Agents
• Immune Checkpoint Inhibitors

Topics

• Antineoplastic Agents (adverse effects, therapeutic use)
• Cancer Survivors
• Cardiotoxicity (diagnosis)
• Cardiovascular System (drug effects)
• Humans
• Immune Checkpoint Inhibitors (adverse effects, therapeutic use)
• Neoplasms (drug therapy)