Abstract |
In locally advanced dermatofibrosarcoma protuberans (DFSP), imatinib mesylate has been described as an efficient neoadjuvant therapy. This retrospective study included patients with locally advanced DFSP who received neoadjuvant TKI ( imatinib or pazopanib) from 2007 to 2017 at Saint Louis Hospital, Paris. The primary endpoint was the evaluation of the long-term status. A total of 27 patients were included, of whom nine had fibrosarcomatous transformation. The median duration of treatment was 7 months. The best response to TKI treatment before surgery, evaluated according to RECIST1.1 on MRI, consisted of complete/partial response (38.5%) or stability (46.2%). DFSP was surgically removed in 24 (89%) patients. A total of 23 patients (85%) were disease-free after 64.8 months of median follow-up (95% confidence interval 47.8; 109.3). One patient developed distant metastases 37 months after surgical tumor resection and finally died. Two patients (7%) did not get surgery because of metastatic progression during TKI treatment, and one patient refused surgery even though the tumor decreased by 30%. Treatment-related adverse events (AE) occurred in 23 patients (85%). Only four patients ( imatinib: n = 3, pazopanib: n = 1) had grade ≥3 AE requiring temporary treatment disruption. Neoadjuvant TKI followed by complete surgery with micrographic analysis is an effective strategy for locally advanced and unresectable DFSP, with durable local recurrence disease-free survival.
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Authors | Jessica Beaziz, Maxime Battistella, Julie Delyon, Cécile Farges, Oren Marco, Cécile Pages, Christine Le Maignan, Laetitia Da Meda, Nicole Basset-Seguin, Matthieu Resche-Rigon, Anouk Walter Petrich, Delphine Kérob, Céleste Lebbé, Barouyr Baroudjian |
Journal | Cancers
(Cancers (Basel))
Vol. 13
Issue 9
(May 06 2021)
ISSN: 2072-6694 [Print] Switzerland |
PMID | 34066400
(Publication Type: Journal Article)
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