Progesterone receptors in normal breast development and breast cancer.

Abstract

Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.

• Authors: Sebastian Giulianelli, Caroline A Lamb, Claudia Lanari
• Journal: Essays in biochemistry (Essays Biochem) Vol. 65 Issue 6 Pg. 951-969 (12 17 2021) ISSN: 1744-1358 [Electronic] England
• PMID: 34061163 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Chemical References

• Progestins
• Receptors, Progesterone
• Progesterone

Topics

• Breast (pathology)
• Breast Neoplasms (drug therapy)
• Female
• Humans
• Progesterone (therapeutic use)
• Progestins (therapeutic use)
• Receptors, Progesterone (therapeutic use)